欧州実験生物学ジャーナル オープンアクセス

抽象的な

A Randomized Controlled Trial of Group Cognitive- Behavior Therapy, Cognitive-Remediation Therapy and Combined Cognitive Therapy on improving function and reducing symptoms for Patients with Schizophrenia

Neda Ali beigi, Parvaneh Mohammadkhani, Robabeh Mazinani, Behrooz Doolatshahi, Hamideh Askari

This research investigates the efficacy of GCBT, GCRT and CCT in reducing positive and negative symptoms of schizophrenic patients and improving their cognitions and social functioning. A Randomized Controlled Trial was used to compare the efficacy of these three methods on patients who receive treatment as usual (TAU). 60 inpatient people with schizophrenia and persistent negative and positive symptoms were selected from Razi hospital in Tehran. Patients were at age 25 to 55 years; had diagnosis of schizophrenia for at least 2 years and were persistent to medication. 40 of them received 32 sessions treatment over 3 months and 20 of them were in waiting list. All Patients received TAU throughout the study. The positive and negative symptoms scales (SAPS & SANS), NOSIE & NCSE completed for all patients on sessions first, eight, sixteenth, twenty fourth, and thirty sixth. Multivariate repeated measure was used for data analysis. Multivariate repeated measure showed the efficacy of combined cognitive therapy. The effect size showed the efficacy of CRT first- CBT next combination on improving cognitive scales but CBT first combined therapy is more effective on general psychopathology. It is more effective on negative and positive scales and behavioral functioning than other types of therapy. GCBT with remediation therapy components is the efficient supplementary therapy in combination with pharmacotherapy in treatment of patients with schizophrenia.