臨床小児皮膚科 オープンアクセス

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美容カンファレンス 2018: テトラヒドロクルクミンの美白効果 Dheeraj Nagore – 皮膚科医

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テトラヒドロクルクミノイド (THC) は、黄色のクルクミノイド (ウコンの根茎から自然に活性な抽出物) から抽出される、天然の水素添加製品で、肌の美白に使用される強力な抗酸化物質として機能します。THC の比類のない抗酸化特性と無色性により、この製品は、天然の合成抗酸化物質、鎮静および抗酸化特性、および UVB 保護を提供する無色の食品および医療用途で有用です。フリーラジカルの蓄積を探索して防止します。また、皮膚のメラニン生成を妨げるチロシナーゼを抑制します。この製品は無色で、他のウコン抽出物の鮮やかな黄色とは異なり、抗老化、皮膚保護、日焼け止め、日焼け後ケアの用途に使用できます。THC は皮膚を保護し、局所用製品で実用的な抗酸化物質として検討する必要があります。テトラヒドロクルクミノイドは、皮膚を老化させる強い放射線、化学物質、その他の環境的ストレス要因にさらされることで生成されるフリーラジカルを探します。クルクミノイドと THC の有効性も濃度に依存しており、THC は低濃度でより有効です。THC は、美容剤の成分として使用される脂肪成分の酸敗を防ぐことで脂肪の自動酸化を阻害し、局所成分の実際の使用期間を延長するのにも役立ちます。THC の鎮静効果と強力な抗酸化作用により、THC は抗老化剤、皮膚サポートおよび美白製品、および全体的な皮膚の健康と美しさを維持するための局所成分の成分として有用です。

Tetrahydrocurcumin (THC), a significant metabolite of curcumin (CUR), has been exhibited to be against cancerogenic and hostile to angiogenic and forestalls type II diabetes. In this current examination, we explored the chemopreventive impacts and fundamental sub-atomic instruments of dietary organization of CUR and THC in azoxymethane (AOM) - incited colon carcinogenesis in mice. All mice were yielded at 6 and 23 wk, and colonic tissue was gathered and analyzed. We found that dietary organization of both CUR and THC could decrease distorted grave foci and polyps arrangement, while THC demonstrated a superior inhibitory impact than CUR. At the sub-atomic level, results from Western smear investigation and immunohistochemistry recoloring demonstrated that dietary CUR and THC displayed calming movement by diminishing

the degrees of inducible NOS and COX-2 through down regulation of ERK1/2 actuation. Furthermore, both dietary

CUR and THC fundamentally diminished AOM-actuated Wnt-1 and β-catenin protein articulation, just as the phosphorylation of GSK-3β in colonic tissue. In addition, dietary taking care of with CUR and THC uniquely diminished the protein level of connexin-43, a significant particle of whole intersections, demonstrating that both CUR and THC may interfere with the intercellular correspondence of grave cells. Taken together, these outcomes exhibited just because the In vivo chemopreventive adequacy and sub-atomic systems of dietary THC against AOM-prompted colonic tumorigenesis.

Antiquated societies utilized botanicals and mineral arrangements of different sorts to encourage skin helping. A few of these materials, looked into as of late, have been found to contain regular catalyst/hormone inhibitors, cell reinforcements and sunscreens. Business skin blanching items in the previous piece of the only remaining century depended on phenolic subordinates, for example, hydroquinone/resorcinol and peroxygenated mercury subsidiaries. © 2008 Sabinsa Corporation 5 The viability of hydroquinone as a skin fading operator was found coincidentally during World War II, when African-American laborers in elastic assembling industrial facilities (where hydroquinone (monobenzone) was a procedure synthetic) grumbled of stained territories on all fours. The innate poisonousness of hydroquinone and mercury activated investigation into more secure botanicals and normal/nature indistinguishable detaches that would accomplish comparable useful impacts. Hydroquinone is known to deliver genuine symptoms whenever utilized over a significant stretch of time. This has led to guidelines or restriction on its utilization in a few nations. For example, in France, hydroquinone use was first confined to 5% and afterward to 2% and current European enactment denies its utilization totally, in beauty care products. The USFDA has ordered hydroquinone as a medication and it is not, at this point endorsed for use in beauty care products. Hydroquinone use is additionally answered to expand the danger of creating leukemia, liver malignant growth, skin aggravation, irreversible hyperpigmentation and regenerative harm. The lasting depigmentation created by hydroquinone photosensitizes the skin and makes it powerless against harm by UV-beams in this way expanding the danger of advancement of skin disease. Most skin lighteners as of now being used are of herbal or regular starting point. Placental proteins and estrogen were utilized before as depigmenting operators, yet are once in a while utilized these days. Ascorbic corrosive subordinates, forexample, ascorbyl acetic acid derivation and ascorbyl palmitate have been utilized for more than 25 years as depigmenting specialists in groupings of 2-3%. These are presently supplanted by the more steady subsidiary magnesium ascorbyl phosphate in a few plans.

化学予防は、がんなどの人間の退行性疾患を予防する比較的新しい有望な治療法であり、天然の食品混合物や合成物質を使用して人間の疾患の進行を阻止、阻害、反対、または阻害することとして定義されます。テトラヒドロクルクミン (THC) は、クルクミン (ウコンの根から抽出) の重要な代謝物です。THC は、酸化ストレスと炎症を予防し、神経変性に作用し、抗がん作用を持つことがわかっています。このレビューでは、THC の化学予防作用の勢いデータと隠れたサブ原子ツール、およびさまざまな人間の疾患の改善に対するその潜在的な効果をまとめます。