D.Srinivasa Rao, S.Ramu, G.Rama Krishna, SD.Muneer
The present research has been undertaken with the aim to develop a topical gel formulation of Diclofenac sodium using different gelling agents carbopol 980, Na CMC, HPMC (K100M) and sodium alginate in different concentration, which would attenuate the gastrointestinal related toxicities associated with oral administration. They were evaluated for physicochemical properties such as homogeneity, grittiness, viscosity, pH, Spreadability, drug content, skin irritancy, in vitro drug release, stability studies. The in vitro drug release rate of gel was evaluated using Franz diffusion cell containing cellophane membrane with phosphate buffer pH 6.8 as the receptor medium. Studies showed that drug release was decreased with increase in gelling agent concentration because polymer concentration increases, viscosity increases. Drug was absorbed from site of application as long as it remains in higher concentration gelling agent in solution form.
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