欧州実験生物学ジャーナル オープンアクセス

抽象的な

Long-term toxicity of pan masala in female swiss mice

Sweety Kumari, Abhijit Dutta and Neeta Lal

The onset of pan masala chewing occurs primarily in early adolescence, leading to addiction in adulthood, not only in males but also among females. No data on females are found, thus the present study targets the damaging effect of pan masala on female swiss mice. The studies were carried out on 15 female swiss mice and were divided into two groups: Control(C) and Pan masala treated (PMT). Lung, liver, kidney and ovary were excised periodically to measure acid phosphatase, alkaline phosphatase, and lactate dehydrogenase activity. Histology of different tissues and serum parameters were also analysed. There was a statistically significant increase in serum parameters and enzymatic activities in lung, liver, kidney and ovary of female swiss mice. Severe damage in the tissue sections was also observed. Pan masala is highly toxic and causes severe damage to the various organs of the female swiss mice. Thus there is a need to put ban on manufacture and sale of such products and the acceleration of the programmes which are aimed at their reduction or elimination from the market.