米国先進ドラッグデリバリージャーナル オープンアクセス

抽象的な

Low Cost and Ecofriendly Phytosynthesis of Silver Nanoparticles Using Cassia roxburghii Stem Extract and its Antimicrobial and Antioxidant Efficacy

Pooja Moteriya and Sumitra Chanda

A new and novel approach for the green synthesis of silver nanoparticles is the need of the hour. Use of plant parts for the synthesis of silver nanoparticles is ecofriendly, economic and cost effective. In the present paper, silver nanoparticles were synthesized using aqueous stem extract of Cassia roxburghii DC as a reducing agent. The biosynthesized AgNPs were characterized by various spectral analysis like UV–Vis, FTIR, XRD, TEM and Zeta potential measurement. UV–vis spectra showed maxima absorption peak at 432 nm. XRD and TEM analysis revealed AgNPs to be facecentered, cubic structures spherical in shape with an average particle size of 32-35 nm. The synergistic antibacterial activity was evaluated against two Gram positive, two Gram negative bacteria and four fungi with fifteen commercial antibiotics alone and antibiotics plus synthesized AgNPs. Antioxidant activity of AgNPs was evaluated by ABTS and FRAP assay. The AgNPs showed synergistic antibacterial activity even better than some antibiotics and also good antioxidant activity. The results suggest that Cassia roxburghii stem could be exploited for the fabrication of AgNPs with potential therapeutic application in nanomedicine especially against multi drug resistant microorganisms which are cost effective and ecofriendly and simple. They can be definitely used in cosmetics, medical and pharmaceutical applications.