Mehdi Faramoushi, Mostafa Khani, BehzadAzadi and Kimiya Sadri
Exercise-induced reduction in maximal force production or the inability to continue activity with enough force is defined as fatigue. Although the etiology of fatigue is complex, but it can be divided into two distinct parts: Central and peripheral which are not separated from each other and have close relationship with each other. Different activities cause fatigue and main challenge is identifying the different mechanisms which are involved in various conditions. Seemingly the traditional justification of the intra cellular accumulation of lactic and hydrogen ions, which cause to dysfunction of contractile protein in mammals, particularly humans, has little significance. In one hand most of the studies about fatigue has been done on isolated animal fiber and in another hand the main issue is putting the dispersed information from different studies together in order to understand the fatigue mechanism in human, particularly athletes. Topics which will be discussed in this study would complete our understanding of the metabolic and hormonal fatigue.
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