臨床エピジェネティクスジャーナル オープンアクセス

抽象的な

Obesity and Endometrial Cancer: Is There a Role for Immunotoxicity?

Eftychia Karoutsou, Petros Karoutsos and Dimitrios Karoutsos

Chronic inflammation and obesity are reciprocal pathophysiological processes underlying the element of the immune response. In obesity, alterations of cytokines are thought to contribute to a low grade inflammation within the adipose tissue affecting the development of several secondary diseases. Although micro-inflammation is involved in the initiation of immune response, excessive inflammation may promote tumor development. This review will discuss the reflexive relationship between endometrial cancer and obesity through immunomodulatory effects exerted by environmental chemicals.