化学研究のアーカイブ オープンアクセス

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Probing the Liver-Heart Axis: Cardiac MRI in Early Assessment of Myocardial Injury in Cirrhosis and Pre-Cirrhosis

Meng Jiang

Cirrhotic cardiomyopathy (CCM), a critical clinical entity in cirrhotic patients, adversely affects post-liver transplantation prognosis and all-cause mortality. However, CCM and its early stages often remain unrecognized when using traditional cardiovascular imaging modalities. In this context, cardiac magnetic resonance (CMR) may play an essential role in the early detection of cardiac insults, by characterization of cardiac impairments with higher resolution (i.e., functional, morphological, and tissue compositional features) and higher sensitivity (e.g., detection of silent myocardial injury). In this mini-review article, we summarized the role of CMR in the assessment of cardiac dysfunction in liver diseases at pre-cirrhotic and cirrhotic stages, and their potential clinical relevance. Here, we emphasize the CMR tissue features in CCM, the capability of CMR in the early detection of silent cardiac impairment at early-stage liver diseases, and the prognostic impacts of CMR findings in cirrhosis.

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