Jae-Hwan N
Obesity is a state of chronic low-grade systemic inflammation, which is characterized by increased proinflammatory cytokine secretion from adipose tissue and the infiltration of leukocytes, including macrophages, into the adipose tissue. Thus, this chronic inflammation impairs insulin signaling in adipocytes, causing insulin resistance, and contributing to the development of metabolic disorders such as cardiovascular disease, type 2 diabetes, and hypertension time.
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