米国先進ドラッグデリバリージャーナル オープンアクセス

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Synthesis and Evaluation of Some New 3-(2’-hydroxy-phenyl)-5-(4’-substituted-phenyl)-2-Pyrazoline-N1-Carboxaldehydes as Antimicrobial Agents

Madhav M. Kendre and Mohammad A. Baseer

In the present investigation, a series of some novel 3-[substituted-2-hydroxy-phenyl]-5-(4’-dimethylamino-phenyl)-2-pyrazoline-1-carboxaldehydes (2a-j) have been synthesized by the treatment of 1-(substituted-2-hydroxy-phenyl)-3-(4’-dimethylamino-phenyl)-prop-2-en-1-one (chalcones) (1a-j) with hydrazine hydrate in hot formic acid using ethanol solvent by conventional method. In 85-95% yield with high purity, the structure of newly synthesized compounds was confirmed by the IR, 1H NMR and Mass spectral analysis. All these newly synthesized compounds were evaluated for their in vitro antimicrobial activity. Most of the compounds showed potent activity.