Sharma Anupam*, Ankalgi Amar Deep, Devi Arti, Ashawat Mahindra Singh
Rheumatoid Arthritis (RA) is an inflammatory autoimmune disease characterized by inflammatory polyarthritis, which affects peripheral joints, especially the small joints of the hands and feet. Rheumatoid arthritis is an autoimmune disorder which occurs when our immune system mistakenly attacks own body’s tissues. Chronic untreated inflammation may promote joint disintegration and joint destruction. It was more often reported in the females as compared to the males and may be caused at any stage of life. The various drug are used in the treatment of Rheumatoid arthritis included the non-steroidal anti-inflammatory drugs, synthetic and biological Disease-Modifying Antirheumatic Drugs (DMARDs), analgesic agents and non-pharmacological measure seeking to alleviate pain, reduce the damage and preserve the joint function but Methotrexate is the most effective drug used in the treatment of rheumatoid arthritis. It must be given in single or in combination. It will help ease symptoms like joint pain, fatigue, redness, and swelling. A large number of methodologies including high performance liquid chromatography, UV-visible, liquid chromatography-mass spectroscopy, mass Spectrophotometry, capillary electrophoresis and electrochemical methods are used for the determination of methotrexate. The various analytical methods were applied directly and easily for the analysis of the Pharmaceutical formulations. The methods were completely validated as per the ICH Q1A (R2) guidelines. Thus this strategy can be safely utilized for the standard quality control analysis of Methotrexate.
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